異膚女童長高針：從三個月大開始

異位性皮膚炎的孩子用 dupilumab 會長高嗎？6-11歲重度異膚試驗中，身高低於第25百分位者治療16週後 30.6% 提升超過5個百分位，安慰劑 11.9%；第50百分位則未達顯著。

張宏嘉 Benjamin Chang 皮膚科專科醫師 · VSKIN 院長 · PSKIN 主治醫師

發表於 2025年4月25日 異位性皮膚炎生物製劑論文導讀

從三個月大開始，小朋友便與異位性皮膚炎為伴。然而，命運的轉折點在她四歲時悄然來臨。那時，她開始接受Dupixent的治療。今天，是她第八次注射這針劑，我和她的媽媽、阿嬤都驚訝地發現，她的身高似乎在不經意間拔高了許多。

這個意外的驚喜不僅在我們的診所被觀察到，也在國際文獻中得到了印證。看到這樣的結果，我們感到無比欣慰和激勵。

在這裡，我也要特別感謝診所的同仁們，感謝她們的支持與包容，願意讓我在醫學美容診的時間治療健保疾病的病人。這份善意與合作，使得我們能夠共同見證這位小朋友的健康成長。願她在未來的日子裡，能夠更加健康、快樂地迎接生命中的每一個美好時刻。

研究背景與重點發現

• 嚴重異位性皮膚炎（AD）會影響兒童的身高發育，這些孩子常見身高低於同齡健康兒童的生長曲線百分位數，並且體重和BMI（身體質量指數）偏高[3][6]。
• 近期多項國際臨床試驗（如LIBERTY AD PEDS）證實，針對6-11歲嚴重異位性皮膚炎兒童，使用Dupixent治療16週後，明顯提升了低於正常生長曲線的兒童的身高百分位數，尤其對於原本身高處於較低百分位（如25%、30%、40%）的族群效果最為顯著[1][2][3][4][5][6]。

具體數據

• 在治療前身高低於第25百分位的兒童中，接受Dupixent治療後有30.6%的人身高提升超過5個百分位，而安慰劑組僅11.9%[1][2][3][4][5][6]。
• 在第30百分位，Dupixent組為31.9%，安慰劑組為11.1%；在第40百分位，Dupixent組為31.3%，安慰劑組為15.5%（上述皆具統計顯著性）[1][2][3][4][5][6]。
• 若以第50百分位作為基準，雖然Dupixent組提升比例（29%）高於安慰劑組（15.7%），但統計上未達顯著差異[1][2][3][4][5][6]。
• 女童治療效果尤為明顯，36.7%接受Dupixent的女童身高提升超過5個百分位，而安慰劑僅1.3%；男童分別為25%與5%[4]。

機轉與臨床意義

• 嚴重異位性皮膚炎會導致慢性炎症，影響骨骼發育與生長激素作用，進而抑制身高成長[3][6]。
• Dupixent有效控制異位性皮膚炎的炎症反應，讓兒童能「追趕」生長曲線，特別是在生長潛力尚未耗盡的低百分位兒童身上效果最明顯[3][5][6]。
• 研究也發現，Dupixent會提升血清骨鹼性磷酸酶（bone ALP）水平，這與骨骼生長活性提升有關，但詳細機制仍在研究中[2][3]。

臨床建議

• 對於因嚴重異位性皮膚炎導致生長受限的兒童，及早且有效地使用Dupixent治療，不僅能改善皮膚症狀，還有助於身高追趕成長，可能帶來長遠的健康益處[2][3][5][6]。
• 對於身高明顯落後於同齡兒童（低於第40百分位）的患者，治療成效最為明顯[1][2][3][5][6]。

「這些數據支持了嚴重異位性皮膚炎兒童在接受Dupixent治療後，能夠顯著改善身高生長，尤其是原本生長受限的孩子。」——歐洲皮膚科學會年會報告[3]

結論

Dupixent注射對於因嚴重異位性皮膚炎導致身高受限的兒童，能顯著促進身高追趕成長，尤其對於原本身高百分位較低的孩子效果最為明顯。及早有效治療異位性皮膚炎，不僅改善皮膚狀況，還有助於兒童的整體生長發育[1][2][3][4][5][6]。

引用：

[1] Could dupilumab help improve height in children with severe atopic… https://touchderma.com/insight/could-dupilumab-help-improve-height-in-children-with-severe-atopic-dermatitis/

[2] [PDF] Abstract N°: 8073 Growth analysis in children aged 6 to 11 years… https://s3.eu-central-1.amazonaws.com/m-anage.com.storage.eadv/abstracts_congress_2024/49547.pdf

[3] Children With Severe AD Catch Up on Growth With Dupilumab https://www.medscape.com/viewarticle/children-severe-ad-catch-growth-dupilumab-2024a1000ivo

[4] Dupilumab May Improve Growth in Children with Severe Atopic… https://www.hcplive.com/view/dupilumab-may-improve-growth-children-severe-atopic-dermatitis-16-weeks

[5] Biologic May Spark Catch-Up Growth in Kids With Eczema https://www.medpagetoday.com/meetingcoverage/aaaai/114498

[6] Maui Derm News: Kids With Severe AD Catch Up on Growth With… https://thedermdigest.com/maui-derm-news-kids-with-severe-ad-catch-up-on-growth-with-dupilumab/

[7] Growth analysis among adolescents with moderate-to-severe atopic… https://pmc.ncbi.nlm.nih.gov/articles/PMC9478921/

[8] Positive Dupixent® (dupilumab) Phase 3 Data in Children Aged 6… https://investor.regeneron.com/news-releases/news-release-details/positive-dupixentr-dupilumab-phase-3-data-children-aged-6-months

[9] Dupixent® (dupilumab) Significantly Reduced Severe Asthma… https://www.prnewswire.com/news-releases/dupixent-dupilumab-significantly-reduced-severe-asthma-attacks-in-children-and-is-the-only-biologic-to-demonstrate-improvement-in-childrens-lung-function-in-a-randomized-phase-3-trial-301150713.html

[10] Dupilumab increases levels of bone growth biomarker irrespective… https://academic.oup.com/bjd/article/191/Supplement_2/ljae266.050/7728651

[11] Frequently Asked Questions About DUPIXENT® (dupilumab) https://www.dupixent.com/frequently-asked-questions

[12] [PDF] PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION… https://www.sanofi.com/assets/countries/canada/docs/products/prescription-products/dupixent-en.pdf

[13] Adverse effects of dupilumab in a child with atopic dermatitis https://www.sciencedirect.com/science/article/pii/S2949913525000072

[14] Dupixent (dupilumab) side effects and what to do about them https://www.medicalnewstoday.com/articles/drugs-dupixent-side-effects

[15] DUPIXENT® (dupilumab) Pediatric EoE Safety Profile https://www.dupixenthcp.com/eoe/efficacy-safety/children-safety-data

[16] Long-term real-world experience of the side effects of dupilumab in… https://pubmed.ncbi.nlm.nih.gov/35238115/

[17] Dupixent Side Effects: What They Are and How to Manage Them https://www.healthline.com/health/drugs/dupixent-side-effects

[18] Child Clinical Study Design | DUPIXENT® (dupilumab) https://www.dupixenthcp.com/atopicdermatitis/efficacy-safety/children-study-designs

[19] Children IGA Efficacy Results | DUPIXENT® (dupilumab) https://www.dupixenthcp.com/atopicdermatitis/efficacy-safety/children-iga-clinical-trial

[20] A phase 2, open‐label study of single‐dose dupilumab in children… https://pmc.ncbi.nlm.nih.gov/articles/PMC7894166/

[21] The effect of atopic dermatitis in pediatric patients on height - PubMed https://pubmed.ncbi.nlm.nih.gov/38013381/

[22] The effect of atopic dermatitis in pediatric patients on height - LWW https://journals.lww.com/md-journal/fulltext/2023/11240/the_effect_of_atopic_dermatitis_in_pediatric.125.aspx

[23] Dupilumab in the treatment of AD in infants and children | DDDT https://www.dovepress.com/a-review-of-dupilumab-in-the-treatment-of-atopic-dermatitis-in-infants-peer-reviewed-fulltext-article-DDDT

[24] Infections in Children Aged 6 Months to 5 Years Treated… - PubMed https://pubmed.ncbi.nlm.nih.gov/38267692/

[25] Early Dupilumab Response Predicts Pediatric Atopic Dermatitis… https://liebertpub.com/doi/full/10.1089/derm.2024.0160?doi=10.1089%2Fderm.2024.0160

[26] Study: Dupixent Improves AD Symptoms in Kids As Young As Six… https://practicaldermatology.com/news/study-dupixent-improves-ad-symptoms-in-kids-as-young-as-six-months/2460898/

[27] Dupilumab Treatment in Pediatric Patients Aged 6–11 Years with… https://pmc.ncbi.nlm.nih.gov/articles/PMC10849907/

[28] Results in Children 6 + Years with Eczema | DUPIXENT® (dupilumab) https://www.dupixent.com/atopicdermatitis/dupixent-results/children

[29] Child Clinical Trial Safety Profile | DUPIXENT® (dupilumab) https://www.dupixenthcp.com/atopicdermatitis/efficacy-safety/children-safety-clinical-trial

[30] Results in Young Children with Eczema | DUPIXENT® (dupilumab) https://www.dupixent.com/atopicdermatitis/dupixent-results/infants

[31] The Application of Dupilumab to Pediatric Patients Aged 6–11yrs… https://pmc.ncbi.nlm.nih.gov/articles/PMC10162094/

[32] Dupixent® (dupilumab) Positive Phase 3 Data in Children 1 to 11… https://newsroom.regeneron.com/news-releases/news-release-details/dupixentr-dupilumab-positive-phase-3-data-children-1-11-years

[33] Dupixent® (dupilumab) Positive Phase 3 Data in Children 1 to 11… https://investor.regeneron.com/news-releases/news-release-details/dupixentr-dupilumab-positive-phase-3-data-children-1-11-years

[34] Pediatric Patients with Eosinophilic Esophagitis Administered… https://www.appliedclinicaltrialsonline.com/view/pediatric-patients-eosinophilic-esophagitis-dupixent-significant-improvements-multiple-disease-measures

[35] Press Release: Dupixent® (dupilumab) Phase 3 trial shows positive… https://www.sanofi.com/en/media-room/press-releases/2022/2022-07-14-05-00-00-2479427

原臉書貼文的標籤 #異膚女童長高針